What if I told you that researchers could cure diseases such as Parkinson's disease and multiple sclerosis? Odds are, you would be in favor of ending the suffering of the thousands of people who currently battle such diseases. These cures and many more are the potential results of embryonic stem cell research. Embryonic stem cells are stem cells isolated from embryos during a specific stage of development known as the blastocyst stage. These stem cells can renew themselves and reproduce to form all cell types of the body. Research utilizing these stem cells requires the destruction of an embryo, making the practice a point of moral, scientific, religious, and political controversy. Many argue that the destruction of embryos for research purposes is unethical based on the belief that embryos qualify as forms of life that deserve respect. Those in favor of embryonic stem cell research deem such a loss acceptable for the future benefits that this research could have on thousands of lives. While various arguments surround this debate, the main point of controversy is the source of stem cells used and the method with which they are obtained. In this paper, I will establish what stem cells are and the difference between embryonic and adult stem cells; then I will evaluate the two main arguments in the embryonic stem cell research debate; and finally, I will analyze the ethics of these arguments to come to the conclusion that embryonic stem cell research is ethical under certain circumstances.
Overview of Stem Cell Research
As defined by "The Human Embryonic Stem Cell Debate: Science, Ethics, and Public Policy," human embryonic stem cells are "a self-renewing cell line that gives rise to all cells and tissues of the body" (Holland 3). Most stem cells are only able to differentiate into a single form of offspring cells, otherwise known as progeny cells. For example, hematopoietic stem cells are a type of stem cells that can only form blood cells and skin stem cells can similarly only produce skin cells. These types of stem cells are referred to as adult stem cells or somatic stem cells because they are gathered from patients after birth (Devolder 5). Meanwhile, embryonic stem cells are pluripotent, meaning they have the capacity to produce all cells and tissues of the body (Holland 5). Embryonic stem cells, however, only have this pluripotent potential for the particular five-to-seven-day stage of embryonic development known as the blastocyst stage, after which they can only reproduce a single cell type ("The Ethics of Embryonic Stem Cell Research" 123).
Stem cells, in general, hold great promise for the future of medicine. Thus far, stem cell-based therapies have been developed to treat illnesses that previously had no cure. One example is bone marrow transplantation to treat leukemia and other blood disorders. The hematopoietic stem cells in bone marrow are injected into a patient who has severely reduced blood cell levels and these stem cells generate new blood cells, restoring the patient's immune system (Devolder 5). Therapies such as this will continue to be discovered with the support of stem cell research.
In addition to the development of revolutionary therapies, stem cell research also provides valuable information about mechanisms regulating cell growth, migration, and differentiation. Scientists can learn about these processes by studying stem cells that have been stimulated to differentiate into different types of body cells. The discovery of new information about these concepts will allow scientists to better understand early human development and how tissues are maintained throughout life (8).
Embryonic stem cells are particularly valuable not only because of their pluripotent qualities, but also because of their ability to renew themselves. This is done by "divid[ing] asynchronously – at different times – into one differentiated daughter cell1 and one stem cell-like daughter cell." This unique self-renewing quality of embryonic stem cells allows them to continuously grow even in laboratory conditions. Other types of stem cells eventually lose the ability to divide, making them less valuable for research purposes. Embryonic stem cells' ability to be produced in large quantities allows researchers to make progress in regenerative medicine, using these cells to develop new functional cells, tissues, and organs. The healthy cells are implanted into the patient, serving as treatment to permanently repair failing organs (Holland 5). The otherwise lack of treatment for loss of organ function displays the valuable potential of embryonic stem cells.
The sources of embryonic stem cells are a main point of controversy in the debate regarding embryonic stem cell research. Some possible sources for these stem cells include embryos created via in vitro fertilization (for either research or reproduction); five-to-nine-week old embryos or fetuses obtained through elective abortion; and embryos created through cloning or what is known as somatic cell nuclear transfer (Liu 1). Somatic cell nuclear transfer is the laboratory creation of a viable embryo by implanting a donor nucleus from a body cell into an egg cell. The ethics of obtaining embryonic stem cells via these sources can be questionable and have led to disputes that I will later address.
Research utilizing human embryonic stem cell lines has focused on the potential to generate replacement tissues for malfunctioning cells or organs (Liu 1). A specific technique has been isolated to utilize stem cells in order to repair a damaged tissue or organ:
"If a damaged tissue or organ cannot repair itself, stem cells could be obtained from these different stem cell sources [organs and tissues from individuals after birth; gametes, tissues, and organs from aborted fetuses; inner cell mass of early embryos]. Scientists could then culture these stem cells by creating conditions that enable them to replicate many times in a petri dish without differentiating. Such a population of proliferating stem cells originating from a single parent group of stem cells is a stem cell line. Stem cells from this stem cell line could then be coaxed to differentiate in to the desired cell type, and be transferred into the patient so that they can repair the damaged tissue or organ" (Devolder 6).
Other examples of research efforts include treatment of spinal cord injury, multiple sclerosis, Parkinson's disease, Alzheimer's disease, and diabetes. Researchers also hope to use specialized cells to replace dysfunctional cells in the brain, spinal cord, pancreas, and other organs (2).
Federal funding of embryonic research has been strictly regulated since 1994 when President Clinton declared such research would not be funded by the government. Following this executive order, Congress passed the Dickey Amendment in 1996, prohibiting "federally appropriated funds from being used for either the creation of human embryos for research purposes or for research in which a human embryo or embryos are destroyed, discarded, or knowingly subjected to risk of injury or death" (Liu 2). Embryonic research has continued nonetheless by means of alternative funding. In 2001, President Bush declared that federal funding would be granted to human embryonic research on a restricted basis. However, these funds were only to be awarded for research on already existing stem cell lines. No funding was to be granted for "the use of stem cell lines derived from newly destroyed embryos, the creation of any human embryos for research purposes, or cloning of human embryos for any purposes" (3-4).
The debate over funding for embryonic stem cell research depends heavily on the ethical status of the research. There are two main arguments surrounding the ethics of embryonic stem cell research: the research is ethical because of the unique potential that embryonic stem cells have to cure currently untreatable diseases; and the research is unethical because it requires the destruction of life in the form of an embryo or fetus. Ultimately, the possible benefits and controversial status of life that an embryo embodies qualify embryonic stem cell research as ethical, as long as the stem cells are obtained in an ethical manner.
Arguments for Embryonic Stem Cell Research
In the realm of stem cell research, embryonic and adult stem cells are often compared. The controversial use of embryonic stem cells is supported on the basis of the many advantages that they have over adult stem cells. Embryonic stem cells are easier to obtain; they have a greater cell growth, otherwise known as proliferation, capacity; and they are more versatile. Embryonic stem cells are isolated from embryos in the blastocyst stage and the process damages the structure of the embryo to a point from which the embryo can no longer develop. Because these stem cells are obtained at a point when the inner cell mass is concentrated in the embryo, they are more easily obtained than adult stem cells, which are limited in quantity. Another valuable benefit of embryonic stem cells is their ability to multiply readily and proliferate indefinitely when cultured in the proper conditions (Devolder 9). Lastly, embryonic stem cells' pluripotent quality is the main factor that distinguishes them from adult stem cells (10). The ability to differentiate into any cell type creates greater possibilities for the application of embryonic stem cells.
Supporters of embryonic stem cell research argue that the research is justified, though it requires the destruction of an embryo, because of the potential for developing cures and preventing unavoidable suffering. These backers often disagree with the belief that "a blastocyst – even one that is not implanted in a woman's uterus – has the same ethical status as a further-developed human" (Clemmitt 702). Arthur Caplan, professor of medical ethics at the University of Pennsylvania, asserts that "an embryo in a dish is more like a set of instructions or blueprint for a house. It can't build the house. For the cells to develop into a human being requires an interactive process in the uterus between the embryo and the mother" (Clemmitt 702).
Others in favor of the research, such as Heron, a biotechnology company, claim that "not to develop the technology would do great harm to over 100 million patients in the United States alone who are affected by diseases potentially treatable by the many medical applications of hES [human Embryonic Stem] cells" (Holland 11-12). One example is the previously stated method of using embryonic stem cells to repair damaged tissue or organs. The only way to restore cellular function in an organ is to literally replace the lost cells and embryonic stem cells provide the best option for producing these cells (3).
Embryonic stem cells do also have some disadvantages that should be considered when making the argument for further support of embryonic stem cell research. Unlike adult stem cells, embryonic stem cells have a higher risk of causing tumor formation in the patient's body after the stem cells are implanted. This is due to their higher capacities for proliferation and differentiation (Devolder 11). Embryonic stem cell-based therapies also possess the risk of immunorejection – rejection of the stem cells by the patient's immune system. Because embryonic stem cells are derived from embryos donated for research after in vitro fertilization treatment, the marker molecules on the surfaces of the cells may not be recognized by the patient's body, and therefore may be destroyed as the result of a defense mechanism by the body (Holland 11). This is a problem that will require a solution if embryonic stem cell research is to be the basis for future therapeutic medicine.
Arguments against Embryonic Stem Cell Research
Currently, the isolation of embryonic stem cells requires the destruction of an early embryo. Many people hold the belief that a human embryo has significant moral status, and therefore should not be used merely as a means for research. One position that opponents of embryonic stem cell research assert is what "The Ethics of Embryonic Stem Cell Research" calls the full moral status view (14). This view holds that "the early embryo has the same moral status, that is, the same basic moral rights, claims, or interests as an ordinary adult human being." This moral status is believed to be acquired at the point of fertilization or an equivalent event such as the completion of somatic cell nuclear transfer. Therefore, with full moral status as a human being, an embryo should not be deliberately destroyed for research purposes simply because it is human (Devolder 15). The Roman Catholic Church is a strong supporter of this view, opposing stem cell research on the grounds that it is a form of abortion. Several other groups, including American evangelicals and Orthodox ethicists, consider "blastocysts to have the same status as fully developed human beings" and therefore oppose embryonic stem cell research for this reason. Beliefs regarding the moral status of an embryo are subjective, and also their own controversial issue, which complicates the task of creating a universal law for the use of embryonic stem cells for research.
Others in opposition, such as Kevin T. Fitzgerald, a Jesuit priest who is a bioethicist and professor of oncology at Georgetown University Medical School, do not consider the moral status of an embryo, but rather assert that Embryos should be protected because they are "that which we all once were" (Clemmitt 701). This view is very similar to moral philosopher and professor of philosophy as the University of California at Irvine Philip Nickel's "Loss of Future Life Problem" in regards to embryonic stem cell research. The Loss of Future Life Problem holds that it is unethical to take the lives of future humans by destroying embryos for research (Tobis 64). This stance stresses the potential of those future lives that will never have the chance to reach fulfillment if destroyed for research. In a retroactive sense, this can cause us to question "what if the embryo that developed into Albert Einstein was destroyed for embryonic stem cell research?" It is impossible for one to know the value that is lost in each embryo taken for research purposes, if that embryo is created with the plan of developing into an adult human being.
The response to this problem is that the particular blastocysts that are harvested for embryonic stem cell research are taken from (1) embryos that are frozen during in vitro fertilization procedures and never implanted, (2) donated egg cells, and (3) embryos created specifically for the purpose of generating new stem cell lines. In each of these cases, the embryo at hand does not have a future life in plan and therefore, nothing is lost by using such embryonic stem cells for research. For embryos created via in vitro fertilization, the researchers using the embryos are not making a decision that results in the loss of a future life. The future life of said embryo is lost when the decision is made to not implant it. Therefore, the Loss of Future Life Problem is not a valid objection to research using embryonic stem cells from frozen IVF embryos that are never implanted. Donated egg cells can be fertilized in a lab or through somatic cell nuclear transfer, a process described earlier in this paper. Embryos created specifically for the purpose of contributing to stem cell research have no actual future life to be lost from the moment of conception. In both of these cases, the intent of fertilization is not to create a future adult human being, and so the Loss of Future Life Problem does not apply to these sources of embryonic stem cells.
"In terms of the Loss of Future Life Problem, the key question is again whether the embryo is being deprived of future life, and again the answer depends on whether the embryo is removed from a woman's reproductive system, in which case it is likely that it is being deprived of future life that it would otherwise go on to have. If fertilization takes place outside a woman's body, by contrast, then the embryo is not already on its way toward a future life, so destroying it does not deprive it of that particular future" (Tobis 66-67).
As shown by the various arguments in this essay, the debate over embryonic stem cell research is a multifaceted scientific, moral, ethical, and political issue. Embryonic stem cells, with their pluripotent potential and self-renewing quality, hold great value for scientific researchers in search of cures for untreatable diseases, progress in regenerative medicine, or a better understanding of early human development. However, the ethical question still arises, "do the ends justify the means?"
Varying views regarding the ethical status of an embryo answer this question in different ways, though it is commonly accepted that if the means of obtaining the embryonic stem cells are ethical, then the resulting research of those stem cells is also ethical. For example, if a donated egg is fertilized in a lab with the intention of being used for future research purposes, the resulting research is therefore morally justified.
This is not to be said that the life of an early-stage embryo is to be taken lightly. More so that our moral perception of these embryos is different than that of a later-stage fetus, an infant, or an adult human being. Phillip Nickel asserts this subconscious difference, claiming that,
"while it's well known that many embryos are shed naturally, in very early abortions and miscarriages, no one makes an effort to save or grieve for them, as frequently happens with later-stage fetuses. This shows that people do view embryos as somewhat different from people, even though they may not realize it" (Clemmitt 702).
Thus, the moral distinction between a blastocyst and a developed fetus weakens the moral arguments in opposition to embryonic stem cell research. After all, if this research can reduce suffering for thousands of people, are we not morally obligated to pursue it?
Scientists in support of embryonic stem cell research are currently restricted by the limited amounts of federal funding and embryonic stem cell lines available for research. Many argue that these restrictions are preventing further scientific development and weakening the United States' position as a leading nation in biomedical research. Some scientists worry that if strict regulations of stem cell research continue, private companies may bypass the standards put in place by the National Institute of Health and conduct unregulated research (Clemmitt 700). If the United States wishes to remain a premiere country in biomedical research and maintain order and control of embryonic research being performed, action must be taken to address this issue.
Overall, though the destruction of a life is typically held to be unethical, the moral status of an embryo in the blastocyst stage is unclear and therefore cannot be equated to the moral status of an adult human being. Also, ethical sources of embryonic stem cells exist that do not take the life of future beings (i.e. unwanted frozen embryos produced via in vitro fertilization, donated egg cells fertilized in a laboratory). For these reasons, in combination with the possibility of reducing suffering for future beings, embryonic stem cell research is ethical under certain circumstances. As long as the stem cells are isolated in a manner that does not harm an embryo with the plan of developing into an adult human, the subsequent research is ethically justified. With this in mind, embryonic stem cell research should receive greater government funding so that continued progress can be made.
1 In cell division, a parent cell divides into two or more daughter cells.
Belin Mirabile was born and raised in Phoenixville, Pennsylvania, a suburb of Philadelphia. She is currently majoring in Mechanical Engineering at Notre Dame with a minor in Catholic Social Tradition. When tasked with the assignment of writing a rhetorical essay that evaluates a point of ethical controversy, Belin wanted to choose a topic that relates to her interest in Bioengineering. Embryonic stem cell research stood out as a current issue that would be interesting to evaluate in the form of a researched essay. After her four years at Notre Dame, Belin plans to pursue a career related to Bioengineering that contributes in some fashion to the betterment of human health. Belin would like to thank her Writing and Rhetoric professor, John Duffy, for transforming her opinion of writing and giving her every tool to be a successful writer.
Clemmitt, Marcia. "Stem Cell Research." CQ Researcher 1 Sept. 2006: 697-720. Web. 25 Nov. 2015.
Devolder, Katrien. The Ethics of Embryonic Stem Cell Research. First ed. 2015. Issues in Biomedical Ethics. Print.
Holland, Suzanne, Lebacqz, Karen, and Zoloth, Laurie. The Human Embryonic Stem Cell Debate: Science, Ethics, and Public Policy. Cambridge, Mass.: MIT, 2001. Basic Bioethics. Web. 17 Nov. 2015.
Liu, Edward Chan-Young. Background and Legal Issues Related to Human Embryonic Stem Cell Research. American Law Division, 2008. Print.
"The Ethics of Embryonic Stem Cell Research." Embryo Politics. Ithaca; London: Cornell UP, 2011. 120. Print.
Tobis, Jerome S., Ronald Baker Miller, and Kristen R. Monroe. Fundamentals Of The Stem Cell Debate : The Scientific, Religious, Ethical, And Political Issues. Berkeley: University of California Press, 2008. eBook Collection (EBSCOhost). Web. 17 Nov. 2015.
Research Paper on Stem Cell
How to start a research paper on stem cell: Tips on how to start
To start a research paper on stem cells, students have to know the basics about them first and narrow down the general topic from there. Conduct initial research and determine what stem cells are, their different kinds, and their existing as well as future uses. Furthermore, as writers go along the step of collecting data, they have to choose a sub-topic that is most interesting for them. They should consider the kind of paper though. For instance, if writing an argumentative paper, the author can choose a specific stance such as being supportive of stem cell use and subsequently provide evidence to sustain this viewpoint. Moreover, writers can explore as many topics and perspectives as possible in order to present compelling arguments which also respond to the strongest counter-positions. On the contrary, if the aim is to write an informative paper, then the tone of writing will be objective or unbiased. After selecting a specific topic, write an outline from the main ideas derived from the research.
Example of an outline
Here is an example of an outline on stem cells.
A.What Are Stem Cells and Why Are They Important to Study?
II.What Are the Different Kinds of Stem Cells?
A.Embryonic Stem Cells
B.Adult Stem cells
C.Perinatal Stem Cells
III.Why Is There a Debate on Using Stem Cells?
IV.What Are the Uses of Stem Cells and How Can Obstacles to Their Use Be Removed?
Example of a stem cell research paper thesis
A thesis includes the main points of the paper. A good thesis is based on thoughtful research and not a simple rewriting of facts. The primary characteristics of a thesis for an argumentative paper are that it must be contestable, specific, focused, and based on evidence. Below is a sample of a thesis on stem cells:
“Stem cells should be used for research because they can reveal the origins of diseases and present effective therapies, especially for those without the cure, while also allowing the testing of these treatments without use for animal or human subjects.”
Example of an introduction
A good introduction should properly state the topic for the readers and hook them from the very start to encourage reading. Many essays start with a general statement for their introductory paragraph followed by supporting sentences. The last sentence is usually the thesis. Here is a sample introduction:
Stem cells have gained significant scientific and public interest as they have the magnificent potential of developing into diverse kinds of cells. When a stem cell divides, in essence, multiplies, each unit has the potential of becoming a replica or another kind with a specialized role, such as brain cell or a red blood cell. Stem cells are important as they produce the entire body of a living thing, while adult stem cells assist in replacing those that are lost due to wear and tear, injuries, or diseases. Stem cells should be used for research because they can reveal the origins of diseases and present effective therapies, especially for those without cure, while also allowing the testing of these treatments without use for animal or human subjects.
How to write body paragraphs: Tips on body writing
A good research paper is composed of well-thought and connected body paragraphs. Each paragraph should be a group of interrelated sentences about a specific idea that ties back to the thesis. The basic components of body paragraphs are a clear topic sentence followed by supporting evidence or details, unity and cohesion, and a concluding sentence that unites the evidence and brings the paper to the next point. Every paragraph must be fully developed with the right number and kind of details or evidence, such as personal examples, quotes from credible sources, and statistics. When writing points that use research, in-text citation is essential to avoid plagiarism. In addition, all paragraphs must have transitions within the sentence and from one body paragraph to the next.
Example of the 1st body paragraph
The first body paragraph should coincide with what is written in the outline. Below is an example of the initial body paragraph:
Stem cells have different kinds. Embryonic stem cells are derived from three- to five-day-old embryos. Also called a blastocyst, this kind has 150 cells. They are likewise pluripotent as they can divide and generate more stem cells or turn into any cell type. Being versatile, embryonic stem cells can regenerate or fix diseased organs and tissues. Adult stem cells are located in many adult tissues, like the bone marrow or fat. Dissimilar to embryonic stem cells, adult stem cells cannot produce different kinds of cells. Perinatal stem cells are found in the amniotic fluid and umbilical cord blood and can also change into specialized cells.
Example of the 2nd body paragraph
The second body paragraph deals with the controversy of stem cells. Here is a sample:
Several critics are against the use of embryonic stem cells per se. Since these stem cells are collected from early-stage embryos, there are questions about this procedure’s morality. Harvesting embryonic stem cells can result in the promotion of abortion as well as the objectification or embryos. In other words, some people fear that embryos will now be made not for the purpose of reproduction but to sell and use for research. Thus, the sanctity of the human body may be sacrificed in pursuit of stem cell therapies.
Example of the 3rd body paragraph
The third body paragraph tackles with the uses of stem cells and the resolutions to controversies. Here is a sample:
Human stem cells can be used for research and find treatment to incurable diseases and remove the need for animal or human experimentation; however, it should be conducted with a moral framework to avoid abuse. Embryonic stem cell research can provide critical information about human development including the formation of diseases. Understanding illnesses at the cellular level, in turn, can produce new therapeutic strategies. Furthermore, stem cells can be used to test new therapies and eliminate animal and human experimentation subjects. Likewise, stem cell research must proceed with an ethical framework to prevent and stop abuses. Related agencies can provide a code of ethics for all scientists to abide.
How to finish a research paper: Tips on conclusion writing
To write a great concluding paragraph, follow these tips. First, summarize all the main arguments. Second, avoid introducing new topics. Third, you can ask provocative questions. Fourth, evoke strong images that can affect the feelings of readers and possibly motivate changes. Fifth, end with a call to action or suggest outcomes and consequences.
Example of a conclusion
Here is a sample conclusion:
Stem cell research has great potential in understanding illnesses and treating incurable diseases apart from ending human and animal experimentation. Nevertheless, it can be abused and turned into a commercial enterprise without regard for human life. As a result, the paper recommends the creation of an ethical framework that will guide stem cell scientists and hold them responsible for the consequences of their actions. While stem cell studies may have some drawbacks, their benefits are far too important to be stunted; thus, the public should support them and ensure that they continue with a strong moral compass for proper guidance.
Tips on research paper revision
Revision is vital to a well-written paper because writing is a discovery process that does not always yield the perfect first draft. Revising your research work enables you to attain the following advantages.
First, you can take a step back from your paper and recognize if everything in it has meaning. Second, you are checking if you said what you truly wanted to express. Third, you evaluate if the writing is clear enough for readers to understand the content. Fourth, if you are writing argumentatively, you can improve the power of your premises. Revising intends to create the best paper after several changes by making it more coherent and persuasive.
Here are the tips to consider for each part of your paper while doing your revisions. For the introduction, determine if it puts your argument within the context of an ongoing conversation on stem cell research. Next, check if this section includes a definition of key terms, draws readers in, and provides a compelling thesis. The next advice is on revising the thesis. Evaluate if the thesis says what you want to say and offers a statement that is worthy of consideration. Furthermore, ensure that the every part of the paper delivers what the thesis promises. Afterwards, assess the structure of the paper. A good practice is making an outline of your written output and determining if it answers your objectives. Make sure that each point is well-developed and improve where necessary. Afterwards, determine the coherency of the paragraphs including transition sentences. Check if all the arguments are logical; any sentence that commits fallacies must be removed. Moreover, determine if the conclusion is appropriate in summing up the main point and motivates readers to think about your arguments.
Do the revision in steps and not in one blow. Rest your eyes for an hour or even days, depending on the time you have, in order to have fresh eyes that are ready to identify and correct mistakes. Read the paper loudly as well as this helps catch many mistakes you may miss when reading by the eye. Lastly, you can ask peers and instructors for feedback and consider all their suggestions during revision.